MCM8- AND MCM9 DEFICIENCIES CAUSE LIFELONG INCREASED HEMATOPOIETIC DNA DAMAGE DRIVING P53-DEPENDENT MYELOID TUMORS

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Summary: Hematopoiesis is particularly bo bichette cleats sensitive to DNA damage.Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy.It is not known why hematopoietic cells are highly vulnerable to DNA damage.Addressing this question is complicated by the paucity of mouse models of hematopoietic malignancie

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Positivity bounds on Higgs-Portal dark matter

Abstract We consider the positivity bounds for WIMP scalar dark matter with effective Higgs-portal couplings up to dimension-8 operators.Taking the superposed states for Standard Model Higgs and scalar dark matter, we show that the part of the parameter space for the effective couplings, otherwise unconstrained by phenomenological bounds, is ruled

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